Coronary Artery Disease held the strongest position in the plaque modification and removal devices market in 2025, accounting for a 62.82% share. This leadership is underpinned by the high procedural focus on coronary interventions, where calcified and complex lesions often require dedicated plaque modification and removal tools to improve device delivery and procedural effectiveness. The established use of these devices in coronary settings, along with the routine integration of interventional cardiology workflows in major treatment centers, continues to support Coronary Artery Disease as the largest application segment in the plaque modification and removal devices market.

Peripheral Artery Disease is emerging as the fastest-growing application in the plaque modification and removal devices market as treatment demand expands beyond coronary care into more diverse vascular interventions. Growth is being supported by the increasing need to manage challenging peripheral lesions, where plaque burden and vessel characteristics often require specialized lesion preparation before definitive treatment. Compared with more established coronary applications, Peripheral Artery Disease is gaining momentum as clinicians broaden the use of plaque modification and removal devices in peripheral procedures where procedural success depends heavily on effective plaque management.

End Use Segment Analysis: Hospitals (Largest Segment) vs Ambulatory Surgical Centers (Fastest-Growing Segment)

Hospitals represented the largest end-use segment in the plaque modification and removal devices market in 2025, with a 71.26% share. Their leadership reflects the concentration of complex cardiovascular and vascular procedures in hospital settings, where advanced imaging access, multidisciplinary clinical teams, and the ability to manage higher-acuity patients support routine use of plaque modification and removal devices. In the plaque modification and removal devices market, hospitals remain the primary venue for these interventions because they are structured to handle demanding cases that require procedural precision and immediate clinical support.

Ambulatory Surgical Centers are the fastest-growing end-use segment in the plaque modification and removal devices market as procedural migration continues toward more efficient outpatient settings. Their momentum is tied to the growing suitability of selected vascular interventions for centers that can deliver streamlined scheduling, shorter stays, and focused procedural workflows. Relative to hospitals, Ambulatory Surgical Centers are seeing wider adoption where patient selection, operational efficiency, and advances in minimally invasive treatment approaches make plaque modification and removal procedures more practical in lower-intensity care environments.